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Submitted by omicsj6789
Thu, 31 Jan 2013
Biosensors are receptors in which bimolecular interactions are used for sensing reactions. Bimolecular interactions, when combined with a microcantilever platform, can generate an efficient biosensing design. The resonance frequency of a microcantilever changes sensitively due to bulk loading from molecular connections as in the case of any sound receptors.
Keywords: Biosensors, Bioelectronics, Biomolecules, Bionanotechnology
In addition, the microcantilevers also undergo bending, if the molecular adsorption is limited only to a single surface of a microcantilever. This cantilever bending is due to a differential surface pressure caused by the forces involved in the adsorption process and is increased by making the cantilever surfaces chemically different.
Lack of uniqueness, the primary drawback of the cantilevers, can be overcome by using incredibly particular biochemical responses such as receptor-ligand, antibody-antigen, or enzyme-substrate reactions. Here we evaluate the microcantilever technological innovation and talk about a number of extremely delicate biochemical indicator applications based on microcantilevers.
During the last fifteen years, microcantilevers (MCLs) have been increasing as a delicate system for the recognition of substances and bioorganisms. Because of their small dimension, light and portable weight, and high surface-to-volume rate, MCL-based receptors enhance our ability to recognize and detect scientific providers by orders of magnitude.
A biosensor is a device used for the detection of an analyte that brings together a biological element with a physicochemical detector element. The MCL biosensors have recently been analyzed in several papers. All of these papers were organized based on realizing scientific components (antibody, compound, necessary proteins, etc.) for identification of analytes. In this evaluation, we plan to summarize the microcantilever biosensors in a format of each particular chemical and bioorganism species to make information on personal biosensors easily accessible.
Microcantilever beams are able to convert molecular identification of biomolecules into a noticeable nanomechanical reaction, being an efficient example of bionanotechnology. Application of MCs to molecular identification is therefore uncomplicated and guarantees to be a cutting-edge in life sciences, such as nanomedicine.
MC beams are generally 0.2-3 micron dense, 20-100 micron extensive wide and 100-800 micron long, and are linked with one end to an appropriate assistance. MC biosensor working concept is very simple. The MC is functionalized with a sensor/probe that can precisely combine the target biochemical species.
Even if molecular systems that regulate MC recognition are simple, the key thermodynamics looks uncomplicated. Let us consider the conventional situation of molecular adsorption on the functionalized top part of a MC. Adsorption is motivated by surface Gibbs free power which results in a change in the out lining area pressure of the MC top part. Bending is therefore straight linked with the energy involved in adsorption. Measurement of bending thus provide an immediate, quantitative way for analyzing the level of the biochemical connections without the need for in-depth knowledge of the molecular information of the forming layer. MC biosensors thus are natural applicants for molecular identification tests in which neon labelling is beyond reach.
Finally, MC biosensors systems are yet developed with appropriate micro fluidic equipment for managing fluids. It follows that execution for on-line application looks possible. To sum up, MC biosensors consist of a constantly increasing novel technological innovation and, because of their exclusive abilities, provide in many situations a resolutive substitute to present biosensor technology, such as the label-free ones. They will perform an important role in upcoming future of bionanotechnology.
For more details please refer our Biosensors Conference.
Author works for OMICS Publishing Group.
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